In accordance with section 504 of the 1973 Rehabilitation Act and the Americans with Disabilities Act, Mississippi State University reasonably accommodates students who demonstrate, through appropriate documentation, a qualified disability. The Disability Resource Center (DRC) is the designated unit on campus where students with disabilities identify themselves when requesting academic accommodations. Disabilities may include but are not limited to, conditions related to mental health, chronic health, attention, learning, autism, brain injury, vision, hearing, mobility, speech or intellectual disabilities. In the case of short-term disabilities (e.g., broken arm), students and instructors can often work to minimize barriers.

The Mississippi State University Writing Center is dedicated to helping all MSU students develop as writers and critical thinkers. The center is available online and in person to writers who want to think about, talk about and work on their writing and the ideas that they want to communicate. The center is staffed by a network of writing consultants including undergraduate and graduate students trained in writing center theory, practice and research as well as faculty from the writing program.

The Center for Academic Excellence supports Mississippi State University students in improving academic performance and in enhancing lifelong learning skills. The center offers diverse services to undergraduate students which include academically enhanced university credit courses, academic support programs, workshops, tutoring services and academic coaching. Open to all university entities, these services promote academic excellence.

The Career Center offers resources, services and programs designed to support students at every stage of their career journey, from exploring potential careers to securing job offers. The center conducts education career fairs and interview days, which provide opportunities for school districts and organizations to share information and interview graduating student teachers and current graduate students each semester.

Mississippi State University Libraries strive to provide exceptional resources, services and facilities to MSU faculty, staff, and students, and the broader community throughout the state of Mississippi and the Southeast. The library is home to the Ulysses S. Grant Presidential Library and the MaxxSouth Digital Media Center, which includes a multimedia lab, makerspace, virtual reality studio and more. The center also serves as MSU's Adobe Creative Campus hub, offering workshops throughout the semester and one-on-one assistance.

The Phil Hardin Foundation Libraries at MSU-Meridian’s College Park and Riley Campuses support the research and information needs of the faculty, staff and students at MSU-Meridian. They provide access to printed and electronic materials, reference assistance, library research help, as well as consultations and library instruction. They also offer teaching/computer labs, a small conference room, and printing and photocopying capabilities.

The Holmes Cultural Diversity Center works to enhance the cultural experiences of students at Mississippi State University and provides services through programs and events offered each year. The center is committed to cultivating a welcoming and inclusive environment that supports underrepresented student populations. They connect students to resources and opportunities to help them grow and improve their overall well-being.

The process of receiving financial aid is a unified effort between the student and the Department of Student Financial Aid. Federal Student Aid Programs include grants, loans and part-time employment. Eligibility for most of these programs is based upon the "demonstrated financial need" of the student applicant and the applicant's family.

MS State Online offers resources to students who are completing courses online. Among these are guides to using online tools, such as Canvas, as well as assistance with technical difficulties.